Kayser-Fleischer ring in a patient with Wilson disease

Kayser-Fleischer rings are golden-brown discolorations of the limbic region of the cornea caused by deposition of copper within the Descemet membrane. They occur in patients with symptomatic Wilson disease, particularly those with neurologic manifestations. Kayser-Fleischer rings reflect the corneal accumulation of copper that has entered the circulation from the liver, and can thus be occasionally found in patients with other cholestatic liver diseases.

Disorders of metal metabolism - Carlos R. Ferreiraa and William A. Gahl